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Watching Neuron Attachments in Real Time
Caption: A living cortical neuron in a culture dish. Red and green dots reveal synapses—potential communication junctions between neurons.Credit: Don Arnold, University of Southern California This...
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Connecting the Dots: The State of U.S. Health, 1990-2010
Caption: Adapted from Figure 2, The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. US Burden of Disease Collaborators. JAMA. 2013 Aug 14;310(6):591-608. Print version...
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Yeast Reveals New Drug Target for Parkinson’s
Caption: Left, yeast sick with too much α-synuclein, a protein that is implicated in Parkinson’s disease. Right, the same yeast cells after a dose of NAB, which seems to reverse the toxic effects of...
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Creative Minds: Lighting Up Memory
One of the most debilitating, and heartbreaking, consequences of Alzheimer’s disease is the way it slowly robs people of their memories. Unfortunately, we don’t yet have a cure for Alzheimer’s, let...
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Introducing AMP: The Accelerating Medicines Partnership
Caption: Lack of efficacy currently accounts for more than half of all drug failures in Phase II clinical studies (left). If AMP’s target validation efforts improve efficacy by 90% (right), the success...
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Creative Minds: Making Sense of Stress and the Brain
Amy ArnstenCredit: Terry Dagradi, Yale School of Medicine Right behind your forehead lies the most recently evolved region of the human brain: the prefrontal cortex (PFC). It’s a major control center...
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Creative Minds: REST-ling with Alzheimer’s Disease
Caption: The REST protein (green) is dormant in young people but switches on in the nucleus of normal aging human neurons (top), apparently providing protection against age-related stresses, including...
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Cool Videos: Alzheimer’s Disease
To keep everyone energized during the hot, hazy days of summer, I’ve decided to start a new series called Cool Videos. This virtual mini-film fest will feature a variety of videos—some even produced...
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Creative Minds: The Muscle-Brain Connection
There’s mounting evidence that exercise has a powerful effect on the human brain. For example, many studies have shown that physical activity appears to reduce the incidence of depression. Exercise can...
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Alzheimer’s-in-a-Dish: New Tool for Drug Discovery
Caption: A plaque (orange) disrupts the normal network of human neurons (green) grown in a three-dimensional gel in the lab, mimicking the brain anatomy of Alzheimer’s patients.Credit: Doo Yeon Kim and...
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NIH-Funded Research Makes Science’s “Top 10” List
Modeled after Time’s Person of the Year, the journal Science has a tradition of honoring the year’s most groundbreaking research advances. For 2014, the European Space Agency nabbed first place with...
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Cool Videos: Coordinated Chaos in the Cell’s Cytosol
When Amy Gladfelter arrived at the University of Basel in Switzerland to pursue post-doctoral work in 2001, she remembers that her research interests were still a little up in the air. As she settled...
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Repurposing an “Old” Drug for Alzheimer’s Disease
Caption: Here I am with Senator Barbara Mikulski (center) and NCATS Director Chris Austin (right). Credit: NIH Alzheimer’s disease research is among the many areas of biomedical science that Senator...
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Brain Imaging: Tackling Chronic Traumatic Encephalopathy
Caption: Left to right, brain PET scans of healthy control; former NFL player with suspected chronic traumatic encephalopathy (CTE); and person with Alzheimer’s disease (AD). Areas with highest levels...
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Creative Minds: Opening a Window on Alzheimer’s Before It Strikes
Yakeel Quiroz While attending college in her native Colombia, Yakeel T. Quiroz joined the Grupo de Neurociencias de Antioquia. This dedicated group of Colombian researchers, healthcare workers, and...
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LabTV: Young Scientist on a Mission to Cure Alzheimer’s Disease
Time for another LabTV video! Today, I’d like you to meet Melissa Young, a third-year graduate student in the College of Pharmacy, University of Georgia, Athens. Young, who is doing research in the...
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Creative Minds: Of Arsenic and Misfolded Proteins
John Hanna Taking out the trash is a must in every household. Inside our cells, it’s also essential because if defective proteins are not properly disposed of, they can accumulate and make a mess of...
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Creative Minds: Applying CRISPR Technology to Cancer Drug Resistance
Patrick Hsu As a child, Patrick Hsu once settled a disagreement with his mother over antibacterial wipes by testing them in controlled experiments in the kitchen. When the family moved to Palo Alto,...
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Got It Down Cold: Cryo-Electron Microscopy Named Method of the Year
Caption: Composite image of beta-galactosidase showing how cryo-EM’s resolution has improved dramatically in recent years. Older images to the left, more recent to the right. Credit: Veronica...
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Creative Minds: Complex Solutions to Inflammation
Hao Wu For nearly 20 years, Hao Wu has studied innate immunity, our body’s first line of defense against infection. One of her research specialties is the challenging technique of X-ray...
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